Clinical Reference Resources
Drug Metabolism Chart
by Robert Barkin, PharmD, MBA, FCP
Many opioid and other analgesic agents are subject to metabolism and elimination via a variety of hepatic enzymes. These elimination pathways may be directly related to impaired or excessive pharmacologic responses, depending on the coadministration of other medications capable of inducing, inhibiting, or competing for access to these enzymes creating significant drug interactions. The following tables identify many of the important pathways involved in analgesic metabolism and may be useful references for determining drug interactions.
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